An introduction to ProLon® for health professionals


ProLon soup in a bowlWhat is ProLon?

ProLon is the first Fasting Mimicking Diet®.

It’s a five-day diet in a box. Each day the user consumes a low calorie diet based on reconstituted dried food, bars and teas, along with a drink that calibrates the energy intake to the mass of the individual.

The macronutrient design is complemented by a daily supplement in the form of a capsule of micronutrients.

The diet has been formulated to provide the user with the benefits of a five day water fast – without the psychological, compliance or physiological issues that an extended water-only fast may generate for many individuals.


What are the purported benefits of ProLon?

reduce visceral fat
reduce measures of inflammatory biomarkers
stimulate beneficial autophagy

Therefore chronic use may increase healthspan.


Valter Longo head and shoulders Who created ProLon?

Valter Longo is a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biological Sciences as well as serving as the director of the USC Longevity Institute. Professor Longo is the inventor of the Fasting Mimicking DietTM and founder of L-Nutra Inc, a company spun out of the University of Southern California to produce ProLon® and further products to treat a range of chronic diseases and foster healthy longevity.

Professor Longo was Scientific Co-chair and keynote speaker at the World Obesity Stock Conference in Sydney 31 March – 1 April 2017.

Professor Longo receives no salary from his company and all proceeds from his shares go to charity. He is devoted to science and to bringing the benefits of his discoveries to the public. Visit his foundation website.

L-Nutra Inc has already spent over USD30 million on research.

Evidence for safety and efficacy

To read studies and view other resources, choose from one or more of these resources (some content is replicated).

The science page on this website
Clinical trials on the company website.
Full details at The Longo Lab.

More about ProLon

The ProLon Fasting Mimicking Diet plan includes five-day, prepackaged meal kits.

  • All meals and snacks are whole-food derived and plant based. The meal kits are low in carbs and protein yet high in healthy fats like olives and flax.
  • During the five-day period, dieters consume only what’s contained within the meal kit.
  • Day one of the diet provides approximately 1,090 kcal (10% protein, 56% fat, 34% carbs), while days two through five provide only 725 kcal (9% protein, 44% fat, 47% carbs).

The low-calorie, high-fat, low-carb content of the meals causes the body to generate energy from noncarbohydrate sources after glycogen stores are depleted (gluconeogenesis). As the fast progresses, ketosis then autophagy are induced.

A specific combination of food is provided for breakfast, lunch, dinner, and snacks, depending on the day.

Because calories vary between days, it’s important that dieters do not mix foods or carry foods over into the next day.

All foods are plant-based, as well as gluten- and lactose-free. The purchased kit comes with nutritional facts.

ProLon recommends that all dieters consult a medical professional – such as a doctor or registered dietitian – before starting the five-day fast.

The ProLon five-day plan is not a one-time cleanse. For most people to derive optimal and lasting results, the diet should be undertaken once a month for three months, then once or twice a year thereafter, depending on the user’s metabolic status.

Want to know more?

You are encouraged to explore this website and the company and product websites in the US and Australia.

Currently learning and support for health care providers is supplied by L-Nutra in the United States.

This will be extended to HCPs in Australia and New Zealand when ProLon is distributed directly within both countries.

Please contact us if you have specific questions. Thanks.

Want to recommend or prescribe ProLon to your clients or patients?

We are developing a simple protocol to make this easy for you.

In the meantime, please send an expression of interest to Peter Jerrim at Please tell Peter your preferred day and time for him to call you. Thank you.