young woman sits on wooden pathway across a tree lined lakeMetabolic pathways

Or what happens when you take ProLon

Fasting is a natural state.

Prolonged fasting is the only way to replace a significant proportion of old cells with new ones.

You run out of fuel in two stages. First your glucose is depleted. Then you start burning fat for fuel. But that’s not fast enough for your normal energy requirements.

So you start to recycle your senescent cells – the old ones that contribute nothing except toxins.

They’re broken into their components, which can be used for energy. And to make new cells.

Fasting phase 1: Day 1–2

Approximately 24–30 hours after your last meal your body will enter the first phase of survival mode. This means it will begin consuming fat and tapping into the glycogen reserves in your muscles while generating new liver glucose.

Fasting phase 2: Day 3–4

After 2 days without food, your body enters the next phase of survival mode. Things are starting to get serious. Beginning on day 2–3, autophagy is triggered.

Autophagy, which means ‘self-eating’, is the process in which cells eat intracellular debris, eliminate waste, and optimise function in order to survive in the low-nutrient environment created by fasting.

Fasting phase 3: Day 5

After four days without food your body is understandably freaking out a little. It has already consumed readily available fat reserves and optimised cell function but the continued fast is subjecting it to some major stress. It’s time for serious action.

At this point the body begins deleting old, inefficient, and damaged cells, while at the same time increasing the number of circulating stem cells available to create new tissue that is young, efficient and strong. This late-stage survival mode phenomenon has been shown to optimise the biological aging of the body. Studies in mice have shown that this process has the potential to prevent or even reverse some chronic diseases!

When fasting places your body through all three phases of its survival mode protocols, it comes out the other side leaner, biologically more efficient, and better equipped to handle the stress of age and daily life thanks to autophagy and stem cell-based regeneration.

After five days of fasting, optimisation has slowed and the body begins to look for alternate sources of energy, including from important tissue such as muscle. After 20 years of fasting and longevity research, The Longevity Institute of the University of Southern California has identified five days as the optimal duration for a fast.

Therefore five days is the optimal period of time in which to follow a fasting mimicking diet such as ProLon.

chart of simplified metabolic pathways during fasting mimicking diet

Regulating growth and ageing

mTOR is a master growth regulator that senses and integrates multiple nutritional and environmental cues.

Lower activity levels in the mTOR pathway and the insulin / growth hormone / IGF-1 axis are associated with longevity.

Regulating sugars and fats

Protein kinase A regulates glycogen, sugar, and lipid metabolism.

Regulating the cell life cycle

The insulin-like growth factor (IGF) signaling pathway mediates cell proliferation, apoptosis (programmed cell death), differentiation, survival, metabolism and migration.

special note

This is a highly simplified description of what actually happens.

Health practitioners: click here to learn more detail and to read the science behind the fasting mimicking diet.