Read the book
First published in Italian in 2017, it outsold the latest Harry Potter book in Italy. Published in English in 2018, it created a sensation.
View the ABC TV Catalyst program
(This is how we first heard about ProLon way back in 2017.)
The potential of fasting to delay aging (Periodic vs. intermittent) 20 January 2021
Professor Valter Longo: fasting and healthy aging 4 December 2020 – AUDIO ONLY
You are what you eat: Fasting as an approach for a healthy long life 5 December 2020
Dr Mark Hyman interviews Professor Valter Longo for Dr Hyman’s podcast The Doctor’s Farmacy. 10 April 2019
Live to 100: Valter Longo, PhD on the Rich Roll Podcast. 21 May 2018
Dr Joseph Mercola, natural health expert, and Professor Valter Longo PhD, discuss the health benefits of the fasting-mimicking diet. 24 July 2017
Eat Fast and Live Longer – At the Rancho Mirage Writers Festival: If the idea of living longer has ever intrigued you, Dr. Valter Longo’s Fasting Mimicking Diet (FMD) may be the secret. New research shows that periodically adopting a diet that mimics the effects of fasting may yield a wide range of health benefits including losing that belly weight, improving cognitive function and living better and longer. Come and hear from the head of the USC Longevity Institute. 21 February 2017
Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis – with Dr Rhonda Patrick. 1 October 2016
Valter Longo: Nutrition, Fasting mimicking diets, Regeneration and Longevity: lecture by Dr Valter Longo from University of Southern California at the Molecular Frontiers Symposium ‘Healthy Ageing’ at Chalmers University of Technology. Aug 2016. Courtesy Molecular Frontiers.
Healthy diet for Healthy life – Valter Longo, Director of Longevity Institute, University of Southern California at University of Teramo. 24 June 2016
Fasting: Awakening the Rejuvenation from Within – Valter Longo at TEDxEchoPark. May 2016
Valter Longo talks about his study of the positive effects of fasting, extreme diets and drugs that mimic them on the prevention and treatment of cancer. Recorded during the 1st Symposium IFOM-EMBL Monterotondo. June 2015
Longevity and Cancer - Valter Longo, IFOM - UCSC Longevity Institute. September 2014
Dr. Valter Longo – Fasting Cycles Retard Growth of Tumors. 8 February 2012
What’s It Worth? host Anthony DiMaggio speaks with Dr. Valter Longo USC about new and innovative chemotherapy treatments and programs. Christmas Eve 2009 radio broadcast to 10 million listeners.
University Of Southern California Davis School of Gerontology Valter Longo explains his recent discovery and the effects it will have on cancer treatment. 2 April 2008
National Geographic 2013
‘On Beyond 100’ in the May 2013 National Geographic magazine includes an account of Valter Longo’s work in Ecuador. Go to the National Geographic website to read the article.
Some ongoing, planned and completed clinical trials
Please contact us for more details.
- Safety, feasibility and metabolic effects of the Fasting Mimicking Diet (FMD) in cancer patients
- Impact of dietary intervention on tumor immunity: The digest trial (digest)
- Os-10-3 a randomized, phase II clinical trial of a controlled diet prior to selected chemotherapy treatment in breast and prostage cancer, to evaluate the impact on toxicity and efficacy
- Phase II study of a diet that simulates fasting in patients undergoing cancer treatment
- BRCA mainhome study
- Short-term fasting prior to platinum-based chemotherapy
- Neoadjuvant chemotherapy for her2 negative breast cancer
- Fasting and nutritional therapy in patients with advanced metastatic prostate cancer
- Fasting and cancer treatment in humans: A case series report
- The effects of short-term fasting on tolerance to (NEO) adjuvant chemotherapy in her-2 negative breast cancer patients: A randomized pilot study
- Safey and feasibility of fasting in combination with platinum-based chemotherapy
- Short-term fasting during chemotherapy in patients with gynecological cancer &emdash; a randomized controlled cross-over trial
- Fasting-mimicking diet in patients receiving chemo-immunotherapy for treatment of metastatic non-small cell lung cancer
- Effects of fasting-mimicking diet on central and peripheral components of fatigue, muscular resistance
- Primitive glomerulonephritis and chronic kidney disease in conservative therapy with egfr ≤ 60 ml/min (3 stage kdoqi)
- Randomized pilot study to evaluate the efficacy and safety of ProLon, a fasting-mimicking diet, as add-on theapy, in Hashimoto’s thyroiditis
- Randomised phase i/ii study of hypoproetic diet in patients with cognitive impairment
- Multiple sclerosis [The safety and tolerability of 3 cycles of a 7 day FMD in patients affected by RRMS, already treated with interferon-beta-1° (22 or 44 mgx3).]
- Randomised contrlled phase I/II trial of hypoproetic diet in patients with metabolic syndrome
- Clinical feasibility and efficacy of intermiitent use of a fasting mimicking diet in the treatment of type 2 diabetes
- To evaluate the efficacy and safety of ProLon, a fasting-mimicking diet on metabolic syndrome
- Evaluate the efficacy and safety of a fasting-mimicking diet, as add-on therapy, on clinical response in patients with active Crohn’s disease
- Five meals a day vs two meals a day
A clinical study will soon be published on the use of Chemolieve in humans undergoing chemotherapy.
And a small trial for patients with metabolic syndrome has been successful. A larger trial is in preparation.
Recent studies for which further information is not yet available
Rangan P., Choi I., et al. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019;26(10):2704-19 e6.
Choi, I.Y., C. Lee, and V.D. Longo, Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol, 2017. PDF
Meanwhile, see some of the other published evidence
Professor Valter Longo is the corresponding author in each of the articles below. His research leading to the fasting-mimicking diet goes back over 20 years.
Click on the image of an article to access it.
Potential to reverse diabetes
Ageing, diabetes, cancer and cardiovascular disease
Enhancing stem cell transplantation
‘[N]utritech interventions have the potential to be safe but also to provide coordinated responses that can trigger sophisticated but dormant programs, such as those activated in response to starvation and refeeding.’
preview article – 2016
Cardiovascular disease and ageing
Animal and plant protein in a macronutritionally balanced diet
Multi-system regeneration, cognitive performance, healthspan, longevity
Ageing, inflammation, hypertension, chronic diseases
‘[T]here is great potential for lifestyles that incorporate periodic fasting during adult life to promote optimal health and reduce the risk of many chronic diseases,[.]’
summative article – 2014/2015
‘[P]rotection from chemotoxicity and retardation of the progression of certain tumors achieved with fasting is not obtained with short-term calorie and/or macronutrient restriction.’
summative article – 2013
‘[P]eriodic protein restriction cycles without [calorie restriction] can promote changes in circulating growth factors and tau phosphorylation associated with protection against age-related neuropathologies.’
animal study – 2013
‘[Fasting can] improve the efficacy of chemotherapy against tumors by protecting normal cells and tissues and possibly by diminishing multidrug resistance in malignant cells.’
summative article – 2012
Diabetes, cancer, cardiovascular disease
Ageing, cancer, diabetes
‘These results provide evidence for a role of evolutionarily conserved pathways in the control of aging and disease burden in humans.’
famous 22-year long study of Ecuadorian individuals who carry mutations in the growth hormone receptor (GHR) gene – 2011
‘[N]ormal cells and mice can be protected against chemotherapy-dependent damage by reducing circulating IGF-I levels and by a mechanism that involves down-regulation of proto-oncogene signals.’
animal study – 2010
‘[Extrapolating from yeast studies, a fasting method] could result in long-term survival for many patients with metastatic cancers, particularly those in which malignant cells have not acquired multidrug resistance.’
discussion paper – 2010
Extending healthy life span
‘[Calorie restriction] results in a consistent reduction in circulating levels of growth factors, anabolic hormones, inflammatory cytokines and oxidative stress markers associated with various malignancies.’
discussion paper with a view to developing chemoprevention agents – 2010