Discover the science behind ProLon

Because it’s your future.

Scroll down to view media and read scientific articles.


Read the book

book cover: The Longevity Diet

First published in Italian in 2017, it outsold the latest Harry Potter book in Italy. Published in English in 2018, it created a sensation.

Buy now

Go to Angus & Roberston to buy The Longevity Diet while you can at the super low price of $18.90.

View the ABC TV Catalyst program

(This is how we first heard about ProLon.)

Videos

Dr Joseph Mercola, natural health expert, and Professor Valter Longo PhD, discuss the health benefits of the fasting-mimicking diet. 24 July 2017

Valter Longo, Ph.D. on Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis – with Dr Rhonda Patrick. 1 October 2016

Eat Fast and Live Longer – At the Rancho Mirage Writers Festival: If the idea of living longer has ever intrigued you, Dr. Valter Longo’s Fasting Mimicking Diet (FMD) may be the secret. New research shows that periodically adopting a diet that mimics the effects of fasting may yield a wide range of health benefits including losing that belly weight, improving cognitive function and living better and longer. Come and hear from the head of the USC Longevity Institute. 21 February 2017

Healthy diet for Healthy life – Valter Longo, Director of Longevity Institute, University of Southern California at University of Teramo. 24 June 2016

Fasting: Awakening the Rejuvenation from Within – Valter Longo at TEDxEchoPark. May 2016

Valter Longo talks about his study of the positive effects of fasting, extreme diets and drugs that mimic them on the prevention and treatment of cancer. Recorded during the 1st Symposium IFOM-EMBL Monterotondo. June 2015

Longevity and Cancer - Valter Longo, IFOM - UCSC Longevity Institute. September 2014

Dr. Valter Longo – Fasting Cycles Retard Growth of Tumors. 8 February 2012

What’s It Worth? host Anthony DiMaggio speaks with Dr. Valter Longo USC about new and innovative chemotherapy treatments and programs. Christmas Eve 2009 radio broadcast to 10 million listeners.

University Of Southern California Davis School of Gerontology Valter Longo explains his recent discovery and the effects it will have on cancer treatment. 2 April 2008

National Geographic 2013

Magazine cover: This baby live to be 120

 
‘On Beyond 100’ in the May 2013 National Geographic magazine includes an account of Valter Longo’s work in Ecuador. Go to the National Geographic website to read the article.

Some ongoing, planned and completed clinical trials

Please contact us for more details.

  • Safety, feasibility and metabolic effects of the Fasting Mimicking Diet (FMD) in cancer patients
  • Impact of dietary intervention on tumor immunity: The digest trial (digest)
  • Os-10-3 a randomized, phase II clinical trial of a controlled diet prior to selected chemotherapy treatment in breast and prostage cancer, to evaluate the impact on toxicity and efficacy
  • Phase II study of a diet that simulates fasting in patients undergoing cancer treatment
  • BRCA mainhome study
  • Short-term fasting prior to platinum-based chemotherapy
  • Neoadjuvant chemotherapy for her2 negative breast cancer
  • Fasting and nutritional therapy in patients with advanced metastatic prostate cancer
  • Fasting and cancer treatment in humans: A case series report
  • The effects of short-term fasting on tolerance to (NEO) adjuvant chemotherapy in her-2 negative breast cancer patients: A randomized pilot study
  • Safey and feasibility of fasting in combination with platinum-based chemotherapy
  • Short-term fasting during chemotherapy in patients with gynecological cancer &emdash; a randomized controlled cross-over trial
  • Fasting-mimicking diet in patients receiving chemo-immunotherapy for treatment of metastatic non-small cell lung cancer
  • Effects of fasting-mimicking diet on central and peripheral components of fatigue, muscular resistance
  • Primitive glomerulonephritis and chronic kidney disease in conservative therapy with egfr ≤ 60 ml/min (3 stage kdoqi)
  • Randomized pilot study to evaluate the efficacy and safety of ProLon, a fasting-mimicking diet, as add-on theapy, in Hashimoto’s thyroiditis
  • Randomised phase i/ii study of hypoproetic diet in patients with cognitive impairment
  • Multiple sclerosis [The safety and tolerability of 3 cycles of a 7 day FMD in patients affected by RRMS, already treated with interferon-beta-1° (22 or 44 mgx3).]
  • Randomised contrlled phase I/II trial of hypoproetic diet in patients with metabolic syndrome
  • Clinical feasibility and efficacy of intermiitent use of a fasting mimicking diet in the treatment of type 2 diabetes
  • To evaluate the efficacy and safety of ProLon, a fasting-mimicking diet on metabolic syndrome
  • Evaluate the efficacy and safety of a fasting-mimicking diet, as add-on therapy, on clinical esponse in patients with active Crohn’s disease
  • Five meals a day vs two meals a day

Breaking news

A clinical study will soon be published on the use of Chemolieve in humans undergoing chemotherapy.

And a small trial for patients with metabolic syndrome has been successful. A larger trial is in preparation.

Recent studies for which further information is not yet available

Rangan P., Choi I., et al. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019;26(10):2704-19 e6.

Choi, I.Y., C. Lee, and V.D. Longo, Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol, 2017. PDF

Meanwhile, see much of the other published evidence

Professor Valter Longo is the corresponding author in each of the articles below. His research leading to the fasting-mimicking diet goes back over 20 years.

Click on the image of an article to access it.


Potential to reverse diabetes

‘[A fasting-mimicking diet] promotes the reprogramming of pancreatic cells in mouse models’
animal study – 2017
image of first page of PDF


Ageing, diabetes, cancer and cardiovascular disease

‘[C]ycles of a 5-day FMD are safe, feasible, and effective in reducing markers/risk factors for aging and age-related diseases.’
clinical study – 2017 image of first page of PDF


Multiple sclerosis

‘The FMD reduced clinical severity in all mice and completely reversed symptoms in 20% of animals.’
animal study – 2016 image of first page of PDF


Cancer

‘[F]asting may confer some protection to host tissues against chemotherapy damage to normal tissues.’
animal study – 2016
An ongoing randomised trial is studying the effect of 72 hours of fasting.
image of first page of PDF


Enhancing stem cell transplantation

‘[N]utritech interventions have the potential to be safe but also to provide coordinated responses that can trigger sophisticated but dormant programs, such as those activated in response to starvation and refeeding.’
preview article – 2016 image of first page of PDF


Cardiovascular disease and ageing

‘[D]ietary interventions have the potential to prevent and even treat cardiovascular disease, which is the leading cause of death.’
research article – 2016 image of first page of PDF


Animal and plant protein in a macronutritionally balanced diet

‘Substitution of plant protein for animal protein, especially that from processed red meat, was associated with lower mortality[.]’
original investigation – 2016 image of first page of PDF


Cancer

‘[C]ombining a fasting-mimicking diet with chemotherapy … [leads to] a major delay in breast cancer and melanoma progression.’
animal study – 2016 image of first page of PDF


Multi-system regeneration, cognitive performance, healthspan, longevity

‘[The] FMD improved metabolism and cognitive function, decreased bone loss and cancer incidence, and extended longevity.’
comparison study in yeast, mice, humans – 2015 image of first page of PDF


Ageing, inflammation, hypertension, chronic diseases

‘[T]here is great potential for lifestyles that incorporate periodic fasting during adult life to promote optimal health and reduce the risk of many chronic diseases,[.]’
summative article – 2014/2015 image of first page of PDF


Reversing immunosuppression

‘[R]educed levels of IGF-1 caused by fasting … regulate hematopoietic stem cell protection, self-renewal, and regeneration.’
article – 2014 image of first page of PDF


Cancer

‘[P]rotection from chemotoxicity and retardation of the progression of certain tumors achieved with fasting is not obtained with short-term calorie and/or macronutrient restriction.’
summative article – 2013
image of first page of PDF


Alzheimer’s disease

‘[P]eriodic protein restriction cycles without [calorie restriction] can promote changes in circulating growth factors and tau phosphorylation associated with protection against age-related neuropathologies.’
animal study – 2013 image of first page of PDF


Cancer

‘[Fasting can] improve the efficacy of chemotherapy against tumors by protecting normal cells and tissues and possibly by diminishing multidrug resistance in malignant cells.’
summative article – 2012 image of first page of PDF


Diabetes, cancer, cardiovascular disease

‘[Dietary restriction may protect against] chronic inflammation, insulin resistance, and dyslipidemia.’
summative article – 2012 image of first page of PDF


Cancer

‘[F]asting-mimicking interventions could enhance the efficacy of existing cancer treatments[.]’
animal study – 2012 image of first page of PDF


Chemotherapy

‘[Fasting] protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs.’
in vitro (yeast) and in vivo (mouse) study – 2012 image of first page of PDF


Ageing, cancer, diabetes

‘These results provide evidence for a role of evolutionarily conserved pathways in the control of aging and disease burden in humans.’
famous 22-year long study of Ecuadorian individuals who carry mutations in the growth hormone receptor (GHR) gene – 2011 image of first page of PDF


Cancer

‘[F]asting for up to 5 days followed by a normal diet, may also protect patients against chemotherapy[.]’
animal study – 2011 image of first page of PDF


Cancer

‘[N]ormal cells and mice can be protected against chemotherapy-dependent damage by reducing circulating IGF-I levels and by a mechanism that involves down-regulation of proto-oncogene signals.’
animal study – 2010 image of first page of PDF


Cancer

‘[Extrapolating from yeast studies, a fasting method] could result in long-term survival for many patients with metastatic cancers, particularly those in which malignant cells have not acquired multidrug resistance.’
discussion paper – 2010 image of first page of PDF


Extending healthy life span

‘Dietary restriction and reduced activity of nutrient-sensing pathways may … [slow aging by mechanisms] which have been conserved during evolution.’
review – 2010 image of first page of PDF


Cancer prevention

‘[Calorie restriction] results in a consistent reduction in circulating levels of growth factors, anabolic hormones, inflammatory cytokines and oxidative stress markers associated with various malignancies.’
discussion paper with a view to developing chemoprevention agents – 2010 image of first page of PDF


Cancer

‘[F]asting was well-tolerated and was associated with a self-reported reduction in multiple chemotherapy-induced side effects.’
human study – 2009 image of first page of PDF


Cancer

‘Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.’
animal study – 2008 image of first page of PDF


Cancer

‘[A] differential stress resistance (DSR) method … focuses … on protecting the organism but not cancer cells against chemotherapy.’
animal study (related to above) –2008 image of first page of PDF


Cancer

‘[F]asting may blunt the side effects of cancer treatment and perhaps even allow patients to tolerate higher drug doses.’
animal study (related to above) – 2008 image of first page of PDF


Read more at the Longo Lab website’s publications page